Losing weight can minimize the risk of cardiovascular diseases related to obesity. Drug therapy is a well-known method of weight reduction. Nevertheless, cardiovascular safety problems with specific slimming drugs raise concerns regarding recently approved medications. Phentermine is endorsed for the short-run therapy of obesity in combination with lifestyle changes. However, many people use it on a regular basis. Topiramate, authorized for the therapy of epilepsy and headache, is also effective for weight loss. A one-dose mixture of low-dose Phentermine and ER version of Topiramate was newly approved by the FDA as a supplement to the lifestyle modification for the therapy of chronic obesity. This article compiles and estimates the cardiovascular risk and benefit ratio related to the use of Phentermine and Topiramate, alone and in conjunction. Cardiovascular information regarding the long-term treatment with ER Topiramate and Phentermine show that this mix can represent a secure and efficient option for losing weight in overweight people at low to the average risk of heart disease.
Combination of Phentermine and ER Topiramate is intended for helping patients with obesity/overweight and weight-related health issues to reduce weight and prevent relapse. Phentermine and ER Topiramate should be used together with a low-calorie intake and workout plan. Phentermine belongs to the group of drugs known as anorectics. It acts by suppressing appetite. Topiramate is considered as an anticonvulsant. This drug acts by reducing appetite and makes you feel full much longer and eat less.
The active component of Phentermine suppresses appetite; therefore, this medication is designed for overweight people who are at risk of such diseases as diabetes, hypertension and high cholesterol. The drug is contraindicated to patients suffering from glaucoma, hyperthyroidism, cardiovascular disorder or ischemic heart disease. People suffering from diabetes or hypertension should be closely monitored. Certain patients have an allergy to the active component of this medication.
Phentermine is available in the ER capsules and tablets. It should be taken once a day in the morning or 3 times a day half an hour before eating. Follow the indications on your prescription label strictly, and consult your physician before starting the treatment. Use the drug properly.
Usually, patients take the medicine for about one month. However, the duration of therapy depends on your reaction to the drug. Phentermine can cause addiction. Avoid increasing the dose and never take it more frequently or longer than necessary.
If you use the ER (long-acting) pills, avoid crushing or splitting the capsule. There are certain pills that can be squeezed and mixed with a meal.
Potential adverse effects
Seek immediate medical assistance if you notice any of the following symptoms of allergy: urticaria; breathing problems; face edema or swollen throat.
Contact your physician as soon as possible if you suffer from a serious adverse effect, for example:
- shortness of breath (even slight);
- breast pain, or if you feel that you may lose consciousness;
- swollen feet;
- increased heart rate or heart palpitation;
- disorientation or nervousness, change of behavior;
- sudden mood swings;
- symptoms of severe hypertension (migraine, vision impairment, tinnitus, worry, disorientation, breast pain, breathing difficulty, irregular heartbeat or cramps).