Aralen, or chloroquine, was developed in 1934 in the German laboratories of Bayer, that is, under the Nazis. It was soon used successfully as a treatment for malaria.
However, now in developed countries, chloroquine is not very intensively used even for its intended purpose due to severe side effects and a thin line between the current dose and the one that can become highly toxic.
Recent studies of chloroquine have found good anti-cancer potential. It turned out that it suppresses stem cells — mainly future cancer cells. Currently, clinical trials are being conducted in which chloroquine is being studied for use in chemotherapy as an additional agent that enhances the effect of chemotherapeutic agents.
Regarding the coronavirus, the situation is as follows. According to one hypothesis, cells that replicate the virus are more susceptible to apoptosis (cell death). If you order Aralen Europe and add a contributing agent, there is a chance that the infected cell will die before the virus leaves it.
According to another hypothesis, chloroquine does not affect the virus in any way. Its target-human immune cells-can get stuck in inflamed tissues and damage them. Less damage to the lungs means a better state of health and the course of the disease with the coronavirus. In particular, the person experiences it not with such a high temperature.
At the same time, to buy chloroquine online and take it can cause the following side effects: nausea, vomiting, abdominal pain, psychosis, convulsive seizures, corneal opacity, retinal damage, visual impairment, ringing in the ears, hair loss, and much more.
Aralen is one of the most effective and widely used antimalarial drugs. The drug causes the death of asexual erythrocyte forms of all types of Plasmodium. It also acts through gamontocides. The drug is well and quickly absorbed and slowly released from the body. You can buy Aralen online for the treatment of acute manifestations of all types of malaria and chemoprophylaxis. The spectrum of action of chloroquine is not limited to the effect on malarial Plasmodium. It has an inhibitory effect on the synthesis of nucleic acids, the activity of certain enzymes, and immunological processes. The drug is widely used in the treatment of collagenases (diffuse lesions of connective tissue): systemic lupus erythematosus, scleroderma, and especially rheumatoid arthritis, in which it is considered as one of the basic drugs. The drug has antiarrhythmic activity: in patients with extrasystole and paroxysmal form of atrial fibrillation, it helps to restore the sinus rhythm. By the nature of the action, it belongs to the group I antiarrhythmic.
Aralen indications are malaria caused by plasmodia sensitive to the drug; prevention of malaria in individuals who have visited endemic areas; amoebiasis; diseases of the joints, connective tissue, and skin (as an additional drug in the treatment of rheumatoid arthritis, systemic lupus erythematosus, photodermatosis, and porphyria).
pathological changes in the retina, and changes in the visual fields of any origin, increased sensitivity to chloroquine derivatives.
With prolonged treatment with the drug in high doses, violations from the visual organ are possible, as well as muscle weakness, muscle spasms, headache, dizziness, tinnitus, hearing disorders, increased excitability, anorexia, nausea, vomiting, diarrhea, abdominal pain, itching, rash, hyperpigmentation of the skin and mucous membranes, hair loss and greying, decreased blood pressure, cardiotoxicity phenomena with changes in ECG.
Short-term treatment is rarely accompanied by the development of side effects. Since some diseases of the connective tissue and joints require prolonged use of the drug, in such cases, it is necessary to conduct control examinations.
Cheap Aralen for sale may have a negative effect on the ability to drive vehicles and perform potentially dangerous work.
Taking the drug requires caution in liver diseases and alcoholism, causing a sharp exacerbation of psoriasis and porphyria.
Chloroquine penetrates into breast milk. If it is necessary to prescribe the drug, it is recommended to stop breastfeeding.
Aralen should not be prescribed during pregnancy for the treatment and prevention of malaria. It has been experimentally established that its use in high doses has a toxic effect on the fetus.
Simultaneous use of the drug with phenylbutazone, gold preparations, penicillamine, cytostatics, levamisole is prohibited. Increased caution is required when taking cimetidine, quinine and other antimalarial agents, GCS, kaolin, antacids, metronidazole, MAO inhibitors, digitalis preparations, chloroquine and when immunizing with oral typhoid vaccine.
The main symptoms of Aralen overdose are collapse (due to the potential cardiotoxicity of the drug), coma, and apnea. After the onset of nausea and vomiting, further symptoms of overdose may occur very quickly. Death can occur as a result of heart and respiratory failure or fatal arrhythmia. Gastric lavage, the appointment of activated carbon, according to indications, that is resuscitation measures, are recommended. If you order chloroquine Europe, it is necessary to monitor the functions of the cardiovascular system (with ECG monitoring, measurement of central venous pressure) and respiratory systems, the level of electrolytes and gases in the blood plasma, if necessary, correct hypokalaemia and acidosis.
With severe intoxication, the following urgent measures are recommended: epinephrine is infused at an initial rate of 0.25 mcg/kg/min and gradually increased by 0.25 mcg/kg/min until systolic blood pressure is restored to a level of at least 100 mm Hg. Epinephrine reduces the effects of chloroquine due to inotropic and vasoconstrictive action.
In case of violation of cardiac conduction, sodium bicarbonate is prescribed for 1-2 mmol/kg every 15 minutes, and in the case of ventricular tachycardia or fibrillation, electro cardioversion is performed. With the exception of life-threatening arrhythmias, other heart rhythm disorders do not require treatment. You should avoid prescribing quinidine as antiarrhythmic drugs.
In the latest research, Chinese scientists have found that this drug can effectively inhibit the infection of a new type of coronavirus. Research results also show that chloroquine also has an immunomodulatory activity that can enhance its antiviral effect in the living body, and the ability to spread widely throughout the body, including in the lungs after oral medication. You can easily find cheap chloroquine for sale and purchase it at an affordable price.