Kaletra is a combination drug that contains lopinavir and ritonavir. Lopinavir is an inhibitor of HIV-1 and HIV-2 protease of the human immunodeficiency virus (HIV) and provides the antiviral activity of Kaletra. Inhibition. HIV protease interferes with the synthesis of virus proteins, which leads to the formation of an immature and makes it impossible for the virus to infect the body. Ritonavir is an inhibitor of HIV-1 and HIV-2 aspartyl proteases for oral administration, an active peptidomimetic.
Inhibition of HIV proteases prevents the gag-poly bond of the polyprotein from breaking, which also leads to the formation of an immature and unable to infect virus. Ritonavir has a selective affinity for HIV protease and shows little activity against human aspartyl protease. It inhibits the CYP3A enzyme-mediated metabolism of lopinavir in the liver, resulting in an increased concentration of lopinavir in blood plasma.
Indications for use
To buy Kaletra online is recommended to treat HIV infection in adults and children over 2 years of age (as part of combination therapy). The choice to buy lopinavir online in the treatment of patients infected with HIV-1 and previously treated with protease inhibitors should be based on the individual determination of virus resistance and previous therapy.
Kaletra is prescribed for HIV or rather helps reduce the number of virus cells in the body and prevent new ones from developing. The drug affects the pathogen, slows its development, as a result, the cell with the disease cannot infect a healthy cell. And the virus gradually dies in the body. The action of ribavirin is also aimed at reducing the number of viable disease cells in the body. Slowing down the development of the pathogen is also possible with the help of interferon beta 1b, which does not allow proteins to mature and has the ability to fight viruses.
Kaletra is not prescribed at:
- severe liver failure;
- simultaneous use with astemizole, terfenadine, midazolam, triazolam, cisapride, pimozide, amiodarone, ergot alkaloids, flecainide, propafenone, rifampicin, and preparations containing St. John’s Wort;
- hypersensitivity to lopinavir, ritonavir and other components of the drug.
Doctors very rarely and with caution advise to order Kaletra Europe for viral hepatitis B and C, cirrhosis of the liver, even with mild to moderate liver failure. It is extremely important to remember that before order lopinavir Europe, you need to take into account the possible increase in the activity of liver enzymes. With caution, the drug is prescribed to patients with hemophilia A and B, as well as people over the age of 65 years.
The drugs lopinavir, ritonavir, and recombinant interferon have some side effects, as does ribavirin. Any of these medications should only be taken with the doctor’s prescription. Detection of any negative impact on the body can be a reason to cancel or replace the drug. Side effects that appeared during the research period of the drug interferon beta 1b were of a distinct nature: from general lethargy, fever, and chills to impaired vision and impaired consciousness. When using ribavirin, there may be side effects from the nervous system and sensory organs, cardiovascular system, respiratory system, gastrointestinal organs, and other disorders. The effect on human skin and hair was observed. Since the drug Kaletra is used for both children and adults, the negative impact on the body is very different. Starting from problems with the internal systems of the body and up to the appearance of syndromes of various nature.
Dosage and administration
– 5 ml of oral solution (400/100 mg twice a day with meals or 10 ml of oral solution (800/200 mg) once a day with meals (for patients with less than three mutations associated with lopinavir).
There is insufficient data to recommend cheap Kaletra for sale once a day in adult patients with three or more mutations associated with lopinavir. Do not use lopinavir/ritonavir once a day in combination with phenobarbital, phenytoin, carbamazepine.
The recommended dose for children aged 6 months to 12 years is 12/3 mg per 1 kg of body weight, 2 times a day. Weighing 7 to 15 kg and 10/2. 5 mg/kg twice daily body weight from 15 to 40 kg (approximately equivalent to 230/57. 5 mg/m2); for children weighing more than 40 kg – the maximum dose of 400/100 mg twice daily (5 ml).
This drug should not be used in children once a day.
In patients who were previously prescribed protease inhibitors, when used in combination with efavirenz, the drug dose should also be increased to 533/133 mg (4 capsules) 2 times/day. However, it should be borne in mind that the indicated dose change may not be sufficient in some patients.
Caution should be exercised in patients with severe renal failure.
Kaletra should be used with caution in patients with moderate liver failure. The recommended initial dose in patients with moderate hepatic insufficiency is 400/100 mg (3 capsules) 2 times/day with meals. Patients with severe liver failure should not be prescribed the drug. Ribavirin in combination with cheap lopinavir for sale and ritonavir works more effectively. Kaletra and ribavirin reinforce each other. You can also take recombinant interferon beta 1b and lopinavir with ritonavir. This combination of drugs also increases the effect of substances on the body. You can also use ribavirin and recombinant interferon beta 1b. All drugs, including cheap ritonavir for sale, act on the principle of introducing the virus into the cell, and weakening it. The pathogen cannot infect healthy cells and stops reproducing. The medicines discussed in this article have analogs, but you should consult the doctor for selection and replacement before buy ritonavir online. Self-administration, appointment, and cancellation may lead to negative consequences in the form of overdose or minor effects on the body of the active substance.
In all pharmacies, before order ritonavir Europe, you can get advice from the pharmacist about the availability, methods of use, selection of analogs of the drug Kaletra, the ability to book it as well as delivery dates. All drug prices are current, however, if you notice a difference between the price of Kaletra in the pharmacy and the search results, please let us know via the feedback form.