Plaquenil is a drug based on the active substance hydroxychloroquine sulfate, which belongs to the pharmaceutical group of antiprotozoal agents. It interacts with free radicals, inhibits the activity of neutral proteases and collagenases contained in rheumatoid nodules, and inhibits the formation of prostaglandins. It is usually prescribed for the treatment of diseases such as rheumatoid arthritis, lupus erythematosus, malaria, etc. in pharmacies of the pharmaceutical market.
According to experts of practical medicine, oral administration of Plaquenil pills and its analogs is an effective therapeutic method for treating diseases such as:
- Rheumatoid arthritis and juvenile rheumatoid arthritis;
- Systemic and discoid lupus erythematosus;
- Various dermatological diseases that develop or worsen as a result of exposure to sunlight.
Plaquenil is used for the treatment of rheumatoid and juvenile rheumatoid arthritis, systemic and discoid lupus erythematosus. You can buy Plaquenil online for the treatment of malaria, as well as the prevention and treatment of acute attacks of malaria, which is caused by Plasmodium vivax, Plasmodium malariae and Plasmodium ovale, as well as sensitive strains of Plasmodium falciparum. Plaquenil is used for definitive treatment of malaria, which is caused by a sensitive strain of Plasmodium falciparum. However, it is not prescribed to order Plaquenil Europe for the treatment of malaria caused by chloroquine-resistant strains of Plasmodium falciparum.
The use of this drug is indicated for adults and children whose ideal weight exceeds 31 kilograms. In calculating the dosage of this drug, a description of the calculation is provided, based on determining exactly the ideal, and not the actual weight of the patient. The minimum effective dose of Plaquenil is determined in the amount of 6.5 milligrams per kilogram of ideal body weight. For an adult patient, this is 200 or 400 mg of the drug. This drug should be taken with a meal or washed down with a glass of milk.
The favorable cost of this drug is offered when purchasing it online. At the same time, customers will be carefully consulted by our specialists, will be able to get all the necessary accompanying documents, and will receive a high level of service.
The development of side effects is possible when taking this drug. They are described in detail in the relevant sections of the instructions for the medical use of the drug. You should remember not to overdose because it can lead to a fatal outcome due to severe respiratory and circulatory disorders. In case of overdose, gastric lavage, oral administration of sorbents is indicated, and there is also evidence of a decrease in the cardiotoxic effect of Plaquenil when taking diazepam.
Plaquenil is not prescribed if the patient has a history of hypersensitivity to hydroxychloroquine sulfate.
Also, the drug is not used if the patient suffers from retinopathy, hereditary lactose intolerance. It is unacceptable to use it in the treatment of pregnant and nursing women as well as children under 6 years of age with a bodyweight of less than 31 kg.
With extreme caution, the drug is used in the treatment of patients suffering from visual impairment, hematological diseases, severe neurological diseases, psychoses, late skin porphyria, kidney failure, glucose-6-phosphate dehydrogenase deficiency, gastrointestinal pathologies, hypersensitivity to quinine.
Use during pregnancy and lactation
Hydroxychloroquine sulfate can penetrate the placental barrier, but data on the use of Plaquenil in the treatment of pregnant women is very limited. It is known that 4-aminoquinolines in therapeutic doses can have a negative effect on the central nervous system of the fetus, cause damage to the auditory nerve, hemorrhage in the retina, and its abnormal pigmentation. In this regard, the use of the drug for this category of patients is possible only in extreme cases.
If you need to use Plaquenil during lactation, you should refuse to breastfeed.
Dosage and administration
Plaquenil in the treatment of malaria is taken orally. On the 1st day in the first reception, use 0.8 g, then after 6 or 8 hours, 0.4 g. On the 2nd and 3rd days, take 0.4 g at a time.
An overdose of Plaquenil is especially dangerous for children, since taking 1 or 2 grams of the drug can cause death. When taking Plaquenil in high doses, the patient may experience headaches, visual impairment, convulsions, collapse, and cardiac conduction disorders.
To eliminate undesirable symptoms, the patient is given gastric lavage, and high doses of activated carbon are provided. Parenteral administration of diazepam is also indicated, if necessary, artificial ventilation is performed, as well as antishock therapy.
The toxic effect on the retina is largely dose-dependent. The incidence of retinopathy with doses up to 6.5 mg/kg of ideal body weight is small. Exceeding the recommended daily dose dramatically increases the risk of developing retinopathy and accelerates its appearance.
Before starting a long course of treatment with the drug, a thorough examination of both eyes should be performed. The examination should include the determination of visual acuity, the examination of the fundus, assessment of color vision, and visual fields. During therapy, such an examination should be performed at least once every 6 months.
If any visual disorders occur (decreased visual acuity, color vision changes), the drug should be immediately discontinued, and the patient’s vision should be carefully monitored, since retinal changes (and visual disorders) may progress even after the drug is discontinued.
We recommend caution in the appointment to buy hydroxychloroquine online to patients with diseases of the liver and kidneys, which may require lower doses of the drug, as well as in connection with the possible impact of the drug on the function of these organs (in severe renal impairment or hepatic the dose should be under the control of the plasma concentrations of hydroxychloroquine).
In patients receiving long-term treatment, a complete blood test should be performed periodically, and in the event of hematological disorders, hydroxychloroquine should be discontinued.
You should inform your doctor about all the drugs you are taking. This also applies to over-the-counter drugs. In particular, you should inform your doctor if you are currently taking digoxin. The doctor will decide whether to stop treatment with cheap Plaquenil for sale or strictly monitor your condition, perhaps to adjust the dose or the intake schedule.